Turkish Journal of Medical Sciences
DOI
-
Abstract
Seven S-aroylmethyl N,N-disubstituted dithiocarbamate derivatives have been synthesized and their effects on oxotremorine induced tremor have been investigated on mice pretreated with the proparkinsonian drug haloperidol. While the compound 1f inhibited oxotremorine-induced tremors at doses of 50 mg/kg and 100 mg/kg levels, compounds 1a, 1c and 1e had this effect at the dose of 100 mg/kg. The compounds 1b, 1d and 1g had no effect on oxotremorine-induced tremors in mice. These results suggest that some of these derivatives have central antimuscarinic effects and antiparkinson activities.
Keywords
Dithiocarbamate, antiparkinson activity
First Page
627
Last Page
630
Recommended Citation
ŞİMŞEK, RAHİME; ŞAFAK, CİHAT; EROL, KEVSER; and VURAL, KAMİL (1999) "S-Aroylmethyl N, N-DisubstitutedDithiocarbamates With Antiparkinson Activity," Turkish Journal of Medical Sciences: Vol. 29: No. 6, Article 6. Available at: https://journals.tubitak.gov.tr/medical/vol29/iss6/6
