Turkish Journal of Medical Sciences
Abstract
Seven S-aroylmethyl N,N-disubstituted dithiocarbamate derivatives have been synthesized and their effects on oxotremorine induced tremor have been investigated on mice pretreated with the proparkinsonian drug haloperidol. While the compound 1f inhibited oxotremorine-induced tremors at doses of 50 mg/kg and 100 mg/kg levels, compounds 1a, 1c and 1e had this effect at the dose of 100 mg/kg. The compounds 1b, 1d and 1g had no effect on oxotremorine-induced tremors in mice. These results suggest that some of these derivatives have central antimuscarinic effects and antiparkinson activities.
DOI
-
Keywords
Dithiocarbamate, antiparkinson activity
First Page
627
Last Page
630
Recommended Citation
ŞİMŞEK, R, ŞAFAK, C, EROL, K, & VURAL, K (1999). S-Aroylmethyl N, N-DisubstitutedDithiocarbamates With Antiparkinson Activity. Turkish Journal of Medical Sciences 29 (6): 627-630. https://doi.org/-
