MAO Inhibitors in Aging: Can They Serve as Protective Agents in Cardiac Tissue Against Oxidative Stress?

Authors

FERHAN KÜLAHÇIOĞLU GİRGİN
MERT ÖZGÖNÜL
GÜLİNNAZ ALPER
GÜLRİZ MENTEŞ
BİLTAN ERSÖZ
ESER YILDIRIM SÖZMEN

DOI

-

Abstract

Biological damage mediated by reactive oxygen species has been increasingly recognized in aging phenomena in recent decades. The increase in catecholamine metabolism is yet another physiological change in aging, predisposing the organism to supranormal hydrogen peroxide produc-tion as a by-product. This study was undertaken to investigate the alterations in oxidant- antioxidant status in rat cardiac tissue during aging. The effects of acute administration of monoamine oxidase (MAO) inhibitors on this status were also investigated to find possible preventive strategies in conjugate aging. MAO activities, malondialdehyde MDA and diene conjugate levels as well as superoxide dismutase and catalase activities were determined in the cardiac tissues of young and aging groups, each consisting of 10 rats. MAO inhibitors (deprenyl and pargy-line) were administered to another two groups of young and aging animals (10 in each group) and the same parameters were also determined in these groups. Cardiac tissue MAO activities (p

Keywords

Monoamine oxidase inhibitors, lipid peroxidation, antioxidant enzymes, cardiac tissue, aging.

First Page

89

Last Page

94

Recommended Citation

GİRGİN, FERHAN KÜLAHÇIOĞLU; ÖZGÖNÜL, MERT; ALPER, GÜLİNNAZ; MENTEŞ, GÜLRİZ; ERSÖZ, BİLTAN; and SÖZMEN, ESER YILDIRIM (1999) "MAO Inhibitors in Aging: Can They Serve as Protective Agents in Cardiac Tissue Against Oxidative Stress?," Turkish Journal of Medical Sciences: Vol. 29: No. 2, Article 2. Available at: https://journals.tubitak.gov.tr/medical/vol29/iss2/2