Turkish Journal of Medical Sciences
DOI
-
Abstract
The daytime and nighttime dispositions of high dose (12 g/m 2 ) methotrexate were examined in 8 osteosarcoma patients. The plasma and renal clearances, urine pH values and area under the curves were compared. The plasma clearance of methotrexate tended to fall after it was administered at (from 1.74±0.06 ml/min/kg to 0.47±0.01 ml/min/kg, p
Keywords
Methotrexate, diurnal variation, Osteosarcoma
First Page
17
Last Page
20
Recommended Citation
SOYKAN, Necdet; ÇINAR, Mehtap; CAN, Cenk; and BİLKAY, Banu Çiçek (1999) "Diurnal Variation of MethotrexatePharmacokinetics in Adults With Osteosarcoma," Turkish Journal of Medical Sciences: Vol. 29: No. 1, Article 4. Available at: https://journals.tubitak.gov.tr/medical/vol29/iss1/4
