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Turkish Journal of Medical Sciences

DOI

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Abstract

The purpose of the study has been to investigate the effect of preand postnatal Cd exposure on conduction velocity of sciatic nerve. Pregnant Swiss albino rats were divided into three groups as control (C), cadmium (Cd) and non-cadmium (NCd) groups. Control animals received tap water while rats in Cd group received Cd as CdCl 2 in their drinking water during the experimental period. The mothers of the NCd group were given Cd during their pregnancy but given tap water after birth. Twenty-two days after birth (postnatal day 22) the rats were separated from the mothers. The present study was performed on 80 rats which were divided into C, NCd, Cd 1 and Cd 2 groups, each including 20 rats. Cd 1 group received CdCl 2 water for an additional 8 days. On postnatal day (PND) 30, conduction velocities and am-plitudes of compound action potentials were determined from sciatic nerves of this group. The other rats were continued to be treated with Cd (Cd 2 group) or tap water (C and NCd groups) for an additional 38 days. On PND, 60, the same measurements wer made for these groups as mentioned above. The means of the peripheral conduction ve-locities decreased significanty in all the Cd-treated groups compared with control group. The mean of the compound action potential amplitudes was significantly decreased only in Cd 2 group compared with control group.

First Page

47

Last Page

52

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