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Turkish Journal of Medical Sciences

Metabolism of Vasoactive Peptides by Human Plasma and Purified Human Aminopeptidase M

DOI

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Abstract

Aminopeptidase M (AmM; EC 3.4.11.2) is a membrane-bound peptidase present on renal brush border and vascular plasma membrane. In the present study, AmM, purified from human placenta hydrolyzed alanyl-, leucyl- and arginyle- /beta- naphtylamides at rates of 3.25±0.04, 1.53±0.04 and 0.68±0.02 µmol/min/mg, respectively, exhibited little or no /alpha-glutamyl-, aspartyl-or glycyl-prolyl-naphthylamidase activities (

First Page

113

Last Page

119

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