Turkish Journal of Chemistry
Abstract
Regio- and stereoselective synthesis of $N$-substituted azole acrylonitriles has been achieved smoothly in $N,N$-dimethylformamide (DMF) in the presence of potassium carbonate (K$_{2}$CO$_{3})$ as a base catalyst. $N$-Substituted azole acrylonitriles were obtained in moderate to good yields (39%-87%) with a one-pot reaction between readily available $N$-acetylazoles and Baylis-Hillman nitriles. The structural determinations were accomplished by NOESY $^{1}$H NMR and X-ray crystallography.
DOI
10.3906/kim-1903-56
Keywords
Baylis-Hillman nitriles, benzimidazole, benzotriazole, $N$-substituted azole acrylonitriles
First Page
1134
Last Page
1148
Recommended Citation
AYDIN, O, KÖKTEN, Ş, ÜNVER, H, & ÇELİK, İ (2019). $N$-Acylazole mediated stereoselective and regioselective synthesis of $N$-substituted azole acrylonitriles. Turkish Journal of Chemistry 43 (4): 1134-1148. https://doi.org/10.3906/kim-1903-56
