Turkish Journal of Chemistry

Editor

Scope of the Special Issue

This special issue invites high-quality submissions presenting groundbreaking research. It aims to bring together academic and industrial researchers from around the world who are interested in a range of disciplines related to biochemistry, such as protein purification and technologies, industrial enzyme applications, molecular biochemistry, biomaterials, and bioprinting.

Key Areas of Focus

• Protein Purification Technologies
  • Advanced chromatographic techniques (affinity, ion-exchange, HIC, SEC) and their applications in protein isolation.
  • Integration of tag-based purification systems and recombinant expression strategies for enhanced yield and purity.
  • Recent innovations in membrane filtration, aqueous two-phase systems, and precipitation-based separation.
  • Analytical methods for assessing protein purity, activity, and structural integrity postpurification.
• Enzyme Technologies
  • Engineering and immobilization strategies to improve enzyme stability, activity, and reusability.
  • Enzyme-based biocatalysis in green chemistry, pharmaceutical synthesis, and industrial processes.
  • Computational enzyme design, directed evolution, and site-directed mutagenesis for performance enhancement.
  • Applications in diagnostics, biosensing, and therapeutic enzyme development.
• Biotechnology and Biotransformation
  • Microbial and enzymatic transformation of natural and synthetic compounds for the synthesis of value-added products.
  • Use of genetically modified organisms (GMOs) and synthetic biology in sustainable production systems.
  • Advances in metabolic engineering, fermentation optimization, and scale-up technologies.
  • Applications in environmental biotechnology, food processing, and bioenergy production.
• Biomaterials, Biosensors, and Bioprinting
  • Design and functionalization of biomaterials for applications in tissue engineering, drug delivery, and regenerative medicine.
  • Development of biosensors for real-time detection of biomolecules, pathogens, and environmental pollutants.
  • Integration of nanomaterials, aptamers, and antibodies into sensor platforms for enhanced sensitivity.
  • 3D bioprinting technologies for organoid fabrication, disease modeling, and personalized medicine applications.
• Determination of Biological Activity
  • In vitro and in vivo methods for assessing pharmacological, antimicrobial, antioxidant, and cytotoxic activities.
  • Cell-based assays and high-throughput screening platforms for functional evaluation.
  • Structure–activity relationship (SAR) studies and bioassay-guided fractionation.
  • Evaluation of therapeutic efficacy and safety of novel compounds and biomaterials.
• Bionanotechnology and Bioengineering
  • Development of nanomaterials for targeted drug delivery, diagnostics, and molecular imaging.
  • Bioengineered systems for controlled release, smart materials, and nanoscale biosensors.
  • Integration of nanotechnology with synthetic biology and tissue engineering platforms.
  • Applications in vaccine delivery, cancer therapy, and antimicrobial nanodevices.
• Molecular Biochemistry
  • Structure–function relationships of proteins, enzymes, nucleic acids, and other biomolecules.
  • Signal transduction pathways, metabolic regulation, and redox biochemistry.
  • Molecular mechanisms of disease and therapeutic target identification.
  • Advanced techniques in structural biology (X-ray, NMR, cryo-EM) and molecular dynamics simulations.
• Bioinformatics and Proteomics
  • Computational modeling, sequence analysis, and database mining for functional annotation of genes and proteins.
  • Proteomic profiling using mass spectrometry, 2D electrophoresis, and label-free quantification.
  • Functional proteomics in disease biomarker discovery and pathway analysis.
  • Integration of omics data for systems biology and personalized medicine applications.
• Bioanalytics, Biophysics, and Biosorption
  • Advanced analytical tools for detection and quantification of biomolecules and small molecules (e.g., LC-MS/MS, FTIR, NMR).
  • Biophysical characterization techniques including spectroscopy, calorimetry, and surface analysis.
  • Biosorption mechanisms for heavy metal removal, wastewater treatment, and bioremediation using biological materials.
  • Development of biosorbent materials and evaluation of kinetic, isotherm, and thermodynamic parameters.
• Biochemistry of Natural Products
  • Isolation, structural elucidation, and functional analysis of bioactive compounds from natural sources.
  • Mechanistic insights into the biosynthesis and metabolic pathways of phytochemicals and secondary metabolites.
  • Therapeutic potential and molecular targets of plant-derived and microbial natural products.
  • Application of natural products in pharmaceuticals, nutraceuticals, and cosmeceuticals.
• Determination of Biomolecules and Metabolites
  • Analytical techniques (e.g., HPLC, GC-MS, ELISA, NMR) for the detection and quantification of metabolites, hormones, and proteins.
  • Metabolomic approaches for biomarker discovery, disease diagnosis, and environmental monitoring.
  • Real-time biosensors and lab-on-a-chip systems for rapid molecular diagnostics.
  • Data analysis and standardization in quantitative and qualitative biomolecule detection.
• Active Pharmaceutical Ingredients and Biopharmaceuticals
  • Design, synthesis, and characterization of APIs for therapeutic use.
  • Development and production of biopharmaceuticals such as monoclonal antibodies, recombinant proteins, and vaccines.
  • Regulatory considerations, quality control, and bioequivalence studies.
  • Drug formulation, delivery, and stability enhancement strategies for biologics and small molecules.
• Drug Discovery, Development, and Delivery Systems
  • High-throughput screening, lead optimization, and preclinical drug evaluation strategies.
  • Novel drug carriers, nanoformulations, and controlled release delivery platforms.
  • Pharmacokinetics, pharmacodynamics, and ADME profiling in drug development pipelines.
  • Translational approaches bridging bench-to-bedside in precision medicine and personalized therapies.

Important Dates

• Submissions open: 15 November 2025
• Submission deadline: 1 February 2026
• Completion of reviewer and editor evaluations: 1 May 2026

For Review and Opinion Papers

Authors wishing to submit review or opinion papers are encouraged to consult with the Guest Editors prior to submission to ensure alignment with the special issue’s objectives.

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