Turkish Journal of Chemistry
Abstract
An efficient synthetic route has been described for the alkylation of 1$H$-indole, 1$H$-benzimidazole, and 1$H$-benzotriazole. This approach features the alkylation of heteroaromatics through in situ generated enones from ketonic Mannich bases under metal-free conditions. A series of alkylated heteroaromatics have been synthesized via the K10 catalyzed alkylation reactions of these heteroaromatics with a variety of ketonic Mannich bases. Environmentally benign K10 catalyst, water-mediated mild reaction conditions, and the efficient synthesis of alkylated products are the advantages of this alkylation method.
DOI
10.3906/kim-1802-18
Keywords
Mannich base, alkylation reaction of 1$H$-indole 1$H$-benzimidazole and 1$H$-benzotriazole, K10, environmentally friendly synthesis
First Page
1598
Last Page
1610
Recommended Citation
SEYİTDANLIOĞLU, P, HANASHALHALSHAHABY, E. H, & ÜNALEROĞLU, C (2018). An efficient water-mediated synthetic route for the alkylation of heteroarenes. Turkish Journal of Chemistry 42 (6): 1598-1610. https://doi.org/10.3906/kim-1802-18
