Turkish Journal of Chemistry
Abstract
One-pot synthesis of novel quinoline- and quinolone-substituted 1,2,3-triazoles has been performed from the key intermediates, quinoline- and quinolone-substituted propargyl derivatives 1-3 (48%-88% yields). The antioxidant properties of the newly synthesized compounds, 1a-1c, 2a-2c, and 3a-3c, were evaluated by monitoring DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging abilities, metal chelating effects, and reducing power. The scavenging effects of compounds on the free radical decreased in the order of 3b$>$ 3a$>$ 1b} and were found to be 36.3%, 34.9%, and 27.6% at the concentration of 500 $\mu $g/mL, respectively. All of the compounds showed low chelating capacity. Furthermore, the antibacterial activity was studied against gram-positive and gram-negative bacteria and the DNA binding ability of the compounds was evaluated with calf thymus DNA using agarose gel electrophoresis.
DOI
10.3906/kim-1804-18
Keywords
Quinoline, quinolone, triazole, antioxidant, antibacteria
First Page
1344
Last Page
1357
Recommended Citation
GÜMÜŞ, AYŞEGÜL and OKUMUŞ, VEYSİ
(2018)
"Synthesis and biological evaluation of quinoline-triazole and quinolone-triazole conjugates,"
Turkish Journal of Chemistry: Vol. 42:
No.
5, Article 13.
https://doi.org/10.3906/kim-1804-18
Available at:
https://journals.tubitak.gov.tr/chem/vol42/iss5/13
