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Turkish Journal of Chemistry

DOI

10.3906/kim-1710-13

Abstract

A one-pot, environmentally friendly, and efficient protocol for the synthesis of novel polyfunctionalized benzo[$a$]pyrimido[5',4':5,6]pyrido[2,3-$c$]phenazine derivatives has been reported by a one-pot, four-component sequential reaction between 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamines, benzaldehydes, and 6-amino-1,3-dimethyluracil in the presence of $p$-TSA as a nontoxic, inexpensive, ecofriendly, and efficacious solid acid catalyst. Two C-C bonds, two C=N bonds, and one C-N bond, as well as two new rings, were formed in this reaction. Through this procedure, compounds with substantial biological and pharmaceutical properties are generated in a single operation. Factors such as high yields, less reaction time, operational simplicity, and lack of any dangerous reagents/solvents have made this process a green one.

Keywords

Multicomponent reactions, microwave irradiation, $p$-TSA, benzo[$a$]pyrimido[5', 4':5, 6]pyrido[2, 3-$c$]phenazine

First Page

1008

Last Page

1017

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