Synthesis and biological properties of novel1-methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene) hydrazine analogues

Authors

ARİF KIVRAK
CAN YILMAZ
METİN KONUŞ
HALİL KOCA
SELAHATTİN AYDEMİR
JEGER ALI OAGAZ

Abstract

1-Methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene)hydrazine analogues were readily prepared in good yields by the reaction of 2-(prop-2-yn-1-yloxy)benzaldehydes and methyl hydrazine. The reaction tolerates a variety of substituents on the 2-hydroxybenzaldehyde to form nitro-, halo-, methoxy-, and naphthyl-substituted 1-methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene)hydrazines. The in vitro antioxidant capacity measurements revealed that among all the analyzed hydrazine analogues that surpassed the Trolox standard, 1-(2-(but-3-ynyl)-5-nitrobenzylidene)-2-methylhydrazine had the maximum value, which was approximately 1.7 times that of Trolox.

DOI

10.3906/kim-1701-42

Keywords

Hydrazines, hydrazones, ABTS, antioxidant capacities, biological properties

First Page

306

Last Page

316

Recommended Citation

KIVRAK, A, YILMAZ, C, KONUŞ, M, KOCA, H, AYDEMİR, S, & OAGAZ, J. A (2018). Synthesis and biological properties of novel1-methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene) hydrazine analogues. Turkish Journal of Chemistry 42 (2): 306-316. https://doi.org/10.3906/kim-1701-42