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Turkish Journal of Chemistry

DOI

10.3906/kim-1703-23

Abstract

The ability of oxime-containing acetylcholinesterase reactivators BT-07 (K005), BT-08 (K033), BT-07-4M (K074), and obidoxime (H$_{2}$LX$_{2}$, X = Cl$^{-}$, Br$^{-})$ to bind palladium(II) or platinum(II) cations was evaluated in aqueous solutions (pH 7.4) at metal-to-ligand molar ratio varying from 1:10 to 10:1. Spectral changes were monitored within a week after mixing the reagents in the range from 220 nm to 500 nm. Results showed that depending on chemical structure and reaction time, oximes form two complex species of composition, [MHL]$^{3+}$ or [M$_{2}$L]$^{4+}$ (M = Pd(II), Pt(II)). It was also found that complexation of platinum(II) ions proceeds slower as compared to palladium(II). Conditional stability constants of new complex species were determined spectrophotometrically using an advanced chemometric procedure, based on the resolution of overlapping bands technique.

Keywords

Bis-quaternary pyridinium aldoximes, acetylcholinesterase reactivators, palladium(II) complexes, platinum(II) complexes, UV-Vis spectroscopy

First Page

418

Last Page

428

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