Turkish Journal of Chemistry
Abstract
1,3-Dipolar cycloaddition of 5-azidomethyl-3-p-substituted phenyl-1,2,4-oxadiazoles to phenyl vinyl sulfone and bismaleimide gives rise straightforwardly to 1-((3-(p-substituted) phenyl-1,2,4-oxadiazol-5-yl)methyl)-4-(phenylsul\-fonyl)-4,5-dihydro-1H-1,2,3-triazoles and bisdihydropyrrolo[3,4-d][1,2,3]triazole-4,6(3aH,5H)-diones. The structures of the new cycloadducts were elucidated by means of IR, NMR (^1H, ^{13}C, 2D), mass spectra, and physical characteristics (mp and R_f values). In addition, anticancer activities of the cycloadducts against MCF-7 cells were also investigated.
DOI
10.3906/kim-1309-59
Keywords
Azide, 1, 3-dipolar cycloaddition, 1, 2, 4-oxadiazole, 1, 2, 3-triazole, pyrrole, anticancer activity
First Page
739
Last Page
755
Recommended Citation
DÜRÜST, Y, KARAKUŞ, H, YAVUZ, M. Z, & GEPDİREMEN, A. A (2014). Synthesis of novel triazoles bearing 1,2,4-oxadiazole and phenylsulfonyl groups by 1,3-dipolar cycloaddition of some organic azides and their biological activities. Turkish Journal of Chemistry 38 (5): 739-755. https://doi.org/10.3906/kim-1309-59
