Synthesis of novel imidazo[1,2-a]pyridines and evaluation of their antifungal activities

Authors

FÜSUN GÖKTAŞ
NESRİN CESUR
DİLEK ŞATANA
MELTEM UZUN

DOI

10.3906/kim-1307-14

Abstract

New 2-(imidazo[1,2-a]pyridin-2-ylcarbonyl)-N-substituted hydrazinecarbothioamides (4a--j), N'-(3-substituted-4-oxo-1,3-thiazolidin-2-ylidene)imidazo[1,2-a]pyridine-2-carbohydrazides (5a--f), and N-(nonsubstituted/4-substituted phenyl)-5-(imidazo[1,2-a]pyridine-2-yl)-1,3,4-oxadiazole-2-amines (6a--d) were synthesized from imidazo[1,2-a]pyridine-2-carbohydrazide (3) and evaluated for antifungal activity against Microsporum gypseum NCPF 580, M. canis, Trichophyton tonsurans NCPF 245, T. rubrum, Candida albicans ATCC 10231, and C. parapsilosis ATCC 22019 using amphotericin B as the standard. The chemical structures of the compounds were confirmed by elemental analysis, IR, ^1H NMR, ^{13}C NMR, HMBC (^{13}C, ^1H), and mass spectra. Most of the tested compounds showed moderate antifungal activity. Hydrazinecarbothioamide derivatives 4h and 4f exhibited the highest activity against M. canis (MIC: 2 \mu g mL^{-1} and 4 \mu g mL^{-1}, respectively).

Keywords

Imidazo[1, 2-a]pyridine, hydrazinecarbothioamide, 4-oxo-1, 3-thiazolidine, 1, 3, 4-oxadiazole, antifungal activity

First Page

581

Last Page

591

Recommended Citation

GÖKTAŞ, FÜSUN; CESUR, NESRİN; ŞATANA, DİLEK; and UZUN, MELTEM (2014) "Synthesis of novel imidazo[1,2-a]pyridines and evaluation of their antifungal activities," Turkish Journal of Chemistry: Vol. 38: No. 4, Article 7. https://doi.org/10.3906/kim-1307-14
Available at: https://journals.tubitak.gov.tr/chem/vol38/iss4/7