Turkish Journal of Chemistry
Abstract
In the presence of water and 1,4-diazabicyclo[2.2.2]octane, several aldehydes and cyclic ketones underwent efficient Knoevenagel condensation with malononitrile and ethyl cyanoacetate to produce the respective \alpha.\beta-unsaturated systems within fairly short time periods. As a result, high yields of conjugated products were easily obtained. Products could be engaged in a Gewald reaction, either stepwise or in situ, to produce efficiently their respective 2-aminothiophenes within 4--7 h.
DOI
10.3906/kim-1309-38
Keywords
Knoevenagel condensation, Gewald reaction, organocatalysis, aqueous conditions, amine
First Page
650
Last Page
660
Recommended Citation
ABAEE, M. S, & CHERAGHI, S (2014). Aqueous DABCO, an efficient medium for rapid organocatalyzed Knoevenagel condensation and the Gewald reaction. Turkish Journal of Chemistry 38 (4): 650-660. https://doi.org/10.3906/kim-1309-38
