Turkish Journal of Chemistry
Abstract
Chemical and biotransformations of a rare diterpene lactone, Gelomulide F (1), from the cytotoxic extract of leaves of Suregada multiflora were studied. Fermentation of compound 1 with Sachromyces cerevisiae transformed it to Gelomulide D (2) and E (3), whereas its treatment with 2N KOH yielded Gelomulide D (2). In addition, a novel compound (4) was obtained by its diastereo and chemoselective reduction with NaBH_4. All of these compounds were characterized on the basis of extensive ^1H-NMR, ^{13}C-NMR, 2D NMR, and mass spectral analyses.
DOI
10.3906/kim-1201-36
Keywords
Diterpene lactone, Gelomulide, Suregada multiflora, Sachromyces cerevisiae, diastereo and chemoselective reduction
First Page
759
Last Page
763
Recommended Citation
GONDAL, H. Y, & CHOUDHARY, M. I (2012). Chemical and biotransformation of Gelomulide F: a rare diterpene lactone. Turkish Journal of Chemistry 36 (5): 759-763. https://doi.org/10.3906/kim-1201-36
