Chemical and biotransformation of Gelomulide F: a rare diterpene lactone

Authors

HUMAIRA YASMEEN GONDAL
MUHAMMAD IQBAL CHOUDHARY

DOI

10.3906/kim-1201-36

Abstract

Chemical and biotransformations of a rare diterpene lactone, Gelomulide F (1), from the cytotoxic extract of leaves of Suregada multiflora were studied. Fermentation of compound 1 with Sachromyces cerevisiae transformed it to Gelomulide D (2) and E (3), whereas its treatment with 2N KOH yielded Gelomulide D (2). In addition, a novel compound (4) was obtained by its diastereo and chemoselective reduction with NaBH_4. All of these compounds were characterized on the basis of extensive ^1H-NMR, ^{13}C-NMR, 2D NMR, and mass spectral analyses.

Keywords

Diterpene lactone, Gelomulide, Suregada multiflora, Sachromyces cerevisiae, diastereo and chemoselective reduction

First Page

759

Last Page

763

Recommended Citation

GONDAL, HUMAIRA YASMEEN and CHOUDHARY, MUHAMMAD IQBAL (2012) "Chemical and biotransformation of Gelomulide F: a rare diterpene lactone," Turkish Journal of Chemistry: Vol. 36: No. 5, Article 10. https://doi.org/10.3906/kim-1201-36
Available at: https://journals.tubitak.gov.tr/chem/vol36/iss5/10