Turkish Journal of Chemistry
DOI
10.3906/kim-0908-201
Abstract
Full details of an enantioselective total synthesis of 8-O-4'-neolignan perseal B are presented for the first time. The synthesis was achieved in 8 steps from vanillin and involved the asymmetric dihydroxylation reaction using AD-mix-\alpha to give the key intermedium (1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)propane-1,2,3- triol, and the Mitsunobu reaction between phenylpropanoid and vanillin formed perseal B. The synthetic method of perseal B exhibits a new route for 8-O-4'-neolignan.
Keywords
Neolignans; perseal B; enantioselective synthesis.
First Page
375
Last Page
380
Recommended Citation
XIA, YAMU; WANG, WEI; GUO, YINGLAN; and LI, JUNFENG
(2010)
"Asymmetric synthesis of 8-O-4'-neolignan perseal B,"
Turkish Journal of Chemistry: Vol. 34:
No.
3, Article 6.
https://doi.org/10.3906/kim-0908-201
Available at:
https://journals.tubitak.gov.tr/chem/vol34/iss3/6
