Turkish Journal of Chemistry
Abstract
A series of 9 new (E)-thiazachalcones (1-3), and their N-alkyl substituted derivatives (4-6), and stereoselective dimerization products (7-9) were synthesized, then tested for antimicrobial activity against all test microorganisms except Pseudomonas aeruginosa. The new compounds (1-6) without dimerization products (7-9) showed good antimicrobial property against Staphylococcus aureus, Listeria monocitogenes, and Enterococcus faecalis. The possible dimerization products of compounds (1-3) were calculated theoretically. Experimental and theoretical calculation showed that \delta-truxinic type dimer is the most stable isomer.
DOI
10.3906/kim-0809-44
Keywords
Thiazachalcones, N-decyl-4-thiazaclaconium bromide, photodimerization, antimicrobial activity.
First Page
621
Last Page
632
Recommended Citation
USTA, A, YAŞAR, A, YAYLI, N, KARAOĞLU, Ş. A, & YAYLI, N (2009). Synthesis of methyl (E)-2',4''-thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities. Turkish Journal of Chemistry 33 (5): 621-632. https://doi.org/10.3906/kim-0809-44
