Synthesis and evaluation of phenytoin derivatives as anticonvulsant agents

Authors

MEENAKSHI DEODHAR
PRAVIN SABLE
ASHOK BHOSALE
KAPIL JUVALE
RAHUL DUMBARE
PRAMOD SAKPAL

Abstract

2,5-Dioxo-4,4-diphenylimidazolidine-1-carboxylic acid (2) was reacted with methyl ester of different amino acids (1a-c) and substituted benzhydrols (3a-b) in pyridine and in the presence of N,N dicyclohexyl carbodiimide (DCC) to yield a series of the title compounds, methyl 2-(2,5-dioxo-4,4-diphenylimidazolidine-1-carboxamido) substituted propanoate (4a-c) and benzhydryl 2,5-dioxo-4,4-diphenyl imidazolidine-1-carboxylate (5a-b). The structures of these compounds were established on the basis of their spectral (IR, ^1H-NMR) data. These newly synthesized derivatives of phenytoin were evaluated in terms of anticonvulsant activity.

DOI

10.3906/kim-0711-18

Keywords

Phenytoin, hydantoin, anticonvulsant activity.

First Page

367

Last Page

373

Recommended Citation

DEODHAR, M, SABLE, P, BHOSALE, A, JUVALE, K, DUMBARE, R, & SAKPAL, P (2009). Synthesis and evaluation of phenytoin derivatives as anticonvulsant agents. Turkish Journal of Chemistry 33 (3): 367-373. https://doi.org/10.3906/kim-0711-18