Synthesis of 1,4-Diazepine Nucleosides

Authors

M. ZIA-UL-HAQ
SHAHID HAMEED
HELMUT DUDDECK
ROSHAN AHMED

DOI

-

Abstract

The phenolic \beta-diketones I prepared by modified Baker-Venkataraman rearrangement were converted to the flavones II in acidic medium which on treatment with aqueous ethylenediamine/propylenediamine gave diazepine derivatives III. After coupling with acetobromo sugars in the presence of mercuric cyanide and nitromethane, deacetylation in methanolic ammonia yielded nucleosides V. The structures of all the intermediates and final products were confirmed with the help of modern spectroscopic techniques.

First Page

807

Last Page

815

Recommended Citation

ZIA-UL-HAQ, M.; HAMEED, SHAHID; DUDDECK, HELMUT; and AHMED, ROSHAN (2002) "Synthesis of 1,4-Diazepine Nucleosides," Turkish Journal of Chemistry: Vol. 26: No. 6, Article 1. Available at: https://journals.tubitak.gov.tr/chem/vol26/iss6/1