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Turkish Journal of Biology

[8-14C] Inosine Metabolism by Streptomyces yokosukanensis ATCC 25520

Muhsin KONUK

Abstract

[8-14C] inosine metabolism by Streptomyces yokosukanensis ATCC 25520, which is one of the producers of nebularine (a purine riboside antibiotic), was investigated in vitro. Inosine was shown not to be a precursor of nebularine (the conversion figure was around 0.29%), and most of the riboside presented (~ 80%) was metabolized along other metabolic routes. In this study fourteen [14C]-labelled purine bases, ribosides and ribotides were identified. They were; purine xathine, guanine, adenine, hypoxanthine, nebularine, xanthosine, guanosine, adenosine, inosine, AMP, IMP, GMP, and GDP.

DOI

-

Keywords

Streptomyces yokosukanensis, nebularine, purine metabolism, inosine

First Page

235

Last Page

239

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