Turkish Journal of Medical Sciences
Abstract
Background/aimWe aimed to determine the relationship between clinical and radiological severity of hand osteoarthritis and serum resistin levels in women diagnosed with metabolic syndrome.Materials and methodsThe study was designed as a case-control study. A total of 87 women aged 50-65 years were evaluated; 29 patients diagnosed with metabolic syndrome and hand osteoarthritis (MetS (+), hand OA (+); Group 1), 29 patients without metabolic syndrome but with hand osteoarthritis (MetS (-), hand OA (+); Group 2) and 29 healthy controls (MetS (-), hand OA (-); Group 3). The diagnostic criteria of American College of Rheumatology (ACR) for hand osteoarthritis and National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) for metabolic syndrome were used. Presence and severity of pain were evaluated according to the Likert scale, function by measuring grip and pinch strength, presence of disability by Duruöz hand score (DHS), and structural damage by Osteoarthritis Research Society International (OARSI) atlas.ResultsThere were no significant differences between the three groups in terms of the presence and severity of pain, functional assessment parameters, disability scores, and serum resistin levels. Structural damage was more severe in Group 2. No significant association was found between serum resistin levels and pain severity, functional assessment parameters, disability scores, hand osteoarthritis findings (total number of tender joints, the total number of nodules, etc.), and structural damage.ConclusionMetabolic syndrome does not contribute to the clinical and radiological severity of hand osteoarthritis. Serum resistin levels are not higher in patients with metabolic syndrome, and have no effect on the severity of hand osteoarthritis.
Author ORCID Identifier
EKİN DOĞANCI: 0000-0003-3886-4093
BERNA AYDOĞAN: 0000-0001-9806-3891
NİLGÜN BAŞKAL: 0000-0001-9157-4816
SAFİYE TUNCER: 0000-0002-8116-3818
DOI
10.55730/1300-0144.5964
Keywords
hand, metabolic syndrome, Osteoarthritis, resistin
First Page
242
Last Page
249
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
DOĞANCI, EKİN BAŞAK; AYDOĞAN, BERNA İMGE; BAŞKAL, NİLGÜN; and TUNCER, SAFİYE
(2025)
"Relationship between hand osteoarthritis severity and serum resistin levels in women with metabolic syndrome: a case-control study,"
Turkish Journal of Medical Sciences: Vol. 55:
No.
1, Article 28.
https://doi.org/10.55730/1300-0144.5964
Available at:
https://journals.tubitak.gov.tr/medical/vol55/iss1/28
