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Turkish Journal of Medical Sciences

Author ORCID Identifier

HÜSEYİN BALCIOĞLU: 0000-0003-1648-3206

ELİF FATMA ÖZKAN PEHLİVANOĞLU: 0000-0002-7529-2576

UĞUR BİLGE: 0000-0002-9310-3070

KADİR UĞUR MERT: 0000-0002-1331-5365

MUHAMMET DURAL: 0000-0001-7227-8114

EBRU ERZURUMLUOĞLU GÖKALP: 0000-0002-1275-5174

OĞUZ ÇİLİNGİR: 0000-0002-5593-4164

SEVİLHAN ARTAN: 0000-0001-7658-6309

DOI

10.55730/1300-0144.5837

Abstract

Background/aim: We aimed to determine the genetic risk factors in the patients (45 years and below) who had early myocardial infarction history in comparison with the people who had no MI over 60 years of age.Material and method: In this study, we chose different age groups to distinguish genetic differences more clearly. Accordingly, we compared those who had MI at an early age with those who were older and did not experience any cardiovascular events. While 99 volunteers under the age of 45 with a history of MI were included as the patient group, 99 volunteers aged 60 and over without MI history were included as the control group. MTHFR (C677T, A1298C), Factor V Leiden (G1691A), Prothrombin (G20210A), PAI (4G/5G) and Factor XIII (V34L), APOA1 (rs670, rs1799837, rs5069) and APOB were studied with blood samples taken from patients.Results: In the logistic regression analysis of thrombophilia markers and gene polymorphisms in the patient and control groups, no statistically significant increase was observed in markers other than APOA1 rs5069 gene polymorphism. APOA1 rs5069 gene polymorphism was found to be higher than those without APOA1 rs5069 gene polymorphism. The frequencies of homozygous MTHFR (C677T, A1298C) and heterozygous Factor XIII V34L were higher in the patient cohort compared to the controls.Conclusion: In our study, we found that prothrombotic gene variants and APOA1 rs5069 polymorphism were statistically significantly related to coronary artery disease. So prothrombotic gene variants and APOA1 rs5069 polymorphism can be predictors of early myocardial infarctions, and those with early family histories can be screened among such mutations.

Keywords

Gene mutation, myocardial infarction at a young age, polymorphism

First Page

682

Last Page

687

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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