Effect of sex-specific abdominal fat tissue composition on WHO/ISUP nuclear grade of clear cell renal cell carcinoma

Authors

ESER BULUTFollow
ALİ KÜPELİFollow
MEHMET AKİF RAMAZANOĞLUFollow
HASAN RIZA AYDINFollow
İBRAHİM SİBALFollow
FATİH BIÇAKLIOĞLUFollow
FATİH YILDIRIMFollow
ŞENOL ADANURFollow
SALİH ALFollow

Author ORCID Identifier

ESER BULUT: 0000-0002-6765-6552

ALİ KÜPELİ: 0000-0002-5322-2972

MEHMET RAMAZANOĞLU: 0000-0002-7637-133X

HASAN AYDIN: 0000-0002-6272-6929

İBRAHİM SİBAL: 0000-0001-6033-7500

FATİH BIÇAKLIOĞLU: 0000-0001-7175-713X

FATİH YILDIRIM: 0000-0002-7544-9430

ŞENOL ADANUR: 0000-0003-0859-1741

SALİH AL: 0000-0001-6999-5745

DOI

10.55730/1300-0144.5850

Abstract

Background/aim: To investigate the relationship between sex-related visceral obesity and WHO/ISUP nuclear grade in clear cell renal cell carcinoma (ccRCC).Materials and methods: Between January 2018 and June 2022, 95 patients (56 men and 39 women) with pathologically proven ccRCC who underwent abdominal computed tomography examination were retrospectively examined. The patients were classified into two groups: low- and high-WHO/ISUP nuclear grade ccRCC (n = 58 and n = 37), respectively. Patient height, weight, body mass index (BMI), sex, age, subcutaneous fat area (SFA), visceral fat area (VFA), total fat area (TFA), and percentage of visceral fat (VF%) were recorded for the two groups. Results: No significant differences were found in age, BMI, SFA, or TFA, but VFA and VF% were significantly higher in the high-grade patient group. In males, maximal tumor diameter (MTD) (67.8% sensitivity and 76.9% specificity) had the highest area under the curve (AUC), while in females, VF% (70.0% sensitivity and 73.7% specificity) had the highest AUC. VF% revealed an odds ratio (OR) of 1.09 in females with high-grade ccRCC, and in males, MTD was an independent predictor of ccRCC with an OR of 1.03.Conclusions: Sex-related body fat tissue, including VFA and VF%, could be used for estimating WHO/ISUP nuclear grade in patients with ccRCC, especially in females.

Keywords

Clear cell carcinoma, computed tomography, neoplasm grading, obesity, renal cell carcinoma

First Page

784

Last Page

791

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

BULUT, ESER; KÜPELİ, ALİ; RAMAZANOĞLU, MEHMET AKİF; AYDIN, HASAN RIZA; SİBAL, İBRAHİM; BIÇAKLIOĞLU, FATİH; YILDIRIM, FATİH; ADANUR, ŞENOL; and AL, SALİH (2024) "Effect of sex-specific abdominal fat tissue composition on WHO/ISUP nuclear grade of clear cell renal cell carcinoma," Turkish Journal of Medical Sciences: Vol. 54: No. 4, Article 22. https://doi.org/10.55730/1300-0144.5850
Available at: https://journals.tubitak.gov.tr/medical/vol54/iss4/22