Do patients infected with human coronavirus before the COVID-19 pandemic have less risk of being infected with COVID-19?

Authors

GAMZE ŞANLIDAĞ İŞBİLENFollow
AYÇA AYDIN UYSALFollow
SELİN YİĞİTFollow
ÖZGÜR APPAKFollow
HİLAL SİPAHİFollow
GÜLENDAM BOZDAYIFollow
ARZU SAYINERFollow
CANDAN ÇİÇEKFollow
ÖZLEM GÜZEL TUNÇCANFollow
OĞUZ REŞAT SİPAHİFollow

Author ORCID Identifier

GAMZE ŞANLIDAĞ İŞBİLEN: 0000-0003-2275-5749

AYÇA UYSAL: 0000-0003-0192-7126

SELİN YİĞİT: 0000-0001-7299-0822

ÖZGÜR APPAK: 0000-0003-1810-8346

HİLAL SİPAHİ: 0000-0003-0387-5171

GÜLENDAM BOZDAYI: 0000-0002-6036-6819

ARZU SAYINER: 0000-0001-6750-2353

CANDAN ÇİÇEK: 0000-0002-3486-8305

ÖZLEM GÜZEL TUNÇCAN: 0000-0003-1611-0725

OĞUZ SİPAHİ: 0000-0002-1243-2746

DOI

10.55730/1300-0144.5846

Abstract

Background/aim: Although seasonal human coronaviruses (HCoVs) have long been recognized as respiratory tract viruses, the newly identified SARS-CoV-2 caused a pandemic associated with severe respiratory failure. We aimed to evaluate the incidence of COVID-19 infection in patients diagnosed in three tertiary teaching hospitals, both with and without prior confirmed HCoV infection, and to compare these cohorts in terms of COVID-19 contraction.Materials and methods: In our study, we examined HCoV PCR-positive cases obtained retrospectively between January 2014 and March 2020 from three University Hospital Microbiology Laboratories (Cohort 1), as well as PCR-negative patients detected in the same PCR cycle as the positive cases (Cohort 2). We also evaluated subgroups of HCoV-positive cases.Results: There was no difference in COVID-19 contraction rates between Cohort 1 and Cohort 2 (p = 0.724). When previous HCoV subgroups of COVID-19-positive patients were examined, no significant difference was found between the betacoronavirus and alphacoronavirus subgroups (p = 0.822), among the four groups (NL63, 229E, OC43, HKU-1) (p = 0.207), or between the OC43 subgroup and the other groups (p = 0.295).Conclusion: Being previously infected with HCoV did not provide protection against COVID-19 in our study group. We suggest evaluating the possible effect of previous OC43 infection on COVID-19 contraction in larger cohorts.

Keywords

COVID-19, epidemiology, HCoV, multiplex PCR, OC43, prevention

First Page

761

Last Page

765

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

ŞANLIDAĞ İŞBİLEN, GAMZE; UYSAL, AYÇA AYDIN; YİĞİT, SELİN; APPAK, ÖZGÜR; SİPAHİ, HİLAL; BOZDAYI, GÜLENDAM; SAYINER, ARZU; ÇİÇEK, CANDAN; GÜZEL TUNÇCAN, ÖZLEM; and SİPAHİ, OĞUZ REŞAT (2024) "Do patients infected with human coronavirus before the COVID-19 pandemic have less risk of being infected with COVID-19?," Turkish Journal of Medical Sciences: Vol. 54: No. 4, Article 18. https://doi.org/10.55730/1300-0144.5846
Available at: https://journals.tubitak.gov.tr/medical/vol54/iss4/18