•  
  •  
 

Turkish Journal of Medical Sciences

Author ORCID Identifier

AYBEGÜM ÖZŞAHİN: 0000-0003-4500-8594

TUBA İLGAR: 0000-0003-2476-8295

SUDEM MAHMUTOĞLU ÇOLAK: 0000-0001-7214-2305

KÜBRA AKYÜZ: 0000-0002-4952-1689

MELİH GÖZÜKARA: 0000-0002-6147-4053

UĞUR KOSTAKOĞLU: 0000-0002-4589-0962

İLKNUR YILDIZ: 0000-0003-2987-0483

AYŞE ERTÜRK: 0000-0001-6413-9165

DOI

10.55730/1300-0144.5845

Abstract

Background and aim: Different side effects, including infections, are encountered in patients receiving anticytokines used for the treatment of severe coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the infections and the effects of these infections that develop in this patient group. Materials and Methods: This study included 208 patients who were followed-up with the diagnosis of severe COVID-19 in two different hospitals. Patient data were obtained retrospectively from the hospital information system. Results: Of the 208 patients included, 54 were in the anakinra group, and 154 were in the tocilizumab group. Of these patients, 73 (35.1%) developed infection, 160 (76.9%) were admitted to the intensive care unit (ICU), and the 30-day mortality rate was 46.6%. The ICU admission, 30-day mortality, and infection rates were higher in the anakinra group, but it was not statistically significant (p = 0.137, p = 0.127, and p = 0.132, respectively), while pneumonia and bloodstream infection (BSI) rates were higher (p = 0.043 and p = 0.010 respectively). The 30-day mortality rate was significantly higher in patients who developed infection, especially in the tocilizumab group (p < 0.001 and p = 0.001). The independent risk factors affecting the development of infection were evaluated via regression analysis, in which it was found that age, sex, and the type of immunosuppressive treatment had no significant effect, while ICU admission increased the risk of infection by 32.8 times (95% CI: 4.4–245.8) and each day of hospitalization slightly increased the risk of infection by 1.06 times (95% CI: 1.03–1.09). Conclusion: Infection rates were higher in the anakinra group, especially the pneumonia and BSI rates were higher than in the tocilizumab group. The 30-day mortality rates were higher in patients who had an infection, especially in the tocilizumab group. This is one of the rare studies that evaluated infections developing in patients treated with anakinra and tocilizumab together.

Keywords

anakinra, Anticytokine, COVID-19, infection, tocilizumab

First Page

752

Last Page

760

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Download

Share

COinS