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Turkish Journal of Medical Sciences

Author ORCID Identifier

İSMAİL SAYGIN: 0000-0002-6013-6378

EMEL ÇAKIR: 0000-0002-9845-366X

SEHER', 'SEHER NAZLI KAZAZ: 0000-0002-8181-000X

ALİ', 'ALİ RIZA GÜVERCİN: 0000-0002-8689-0571

İLKER EYÜPOĞLU: 0000-0002-7732-1289

MÜŞERREF', 'MÜŞERREF MÜGE USTAOĞLU: 0000-0002-8414-5324

DOI

10.55730/1300-0144.5843

Abstract

Background/aim : Meningiomas are the most common primary brain tumors of the central nervous system. Immunotherapy is a promising treatment method applied in many types of cancer. There is no standard and effective medical treatment to reduce recurrence and mortality in cases of incomplete resection of meningiomas and in high-grade cases. In order to investigate medical treatments in addition to surgery and radiotherapy, in this study, the status of immune checkpoint molecules (PD-L1/PD-1), which are the target of immunotherapy, in meningiomas was investigated.Materials and Methods: Four hundred two cases of meningioma diagnosed between 2007 and 2020 in our institution were used. New blocks were prepared from the appropriate blocks of the cases using the tissue microarray method. Sections obtained from these blocks were immunohistochemically stained with PD-1, PD-L1 antibodies. Obtained data were interpreted with statistical analysis.Results: Expression of PD-L1 was observed in 28.4% of meningiomas. Staining rates are higher in high-grade tumors. The staining rate of PD-L1 in the tumor increased significantly with pattern loss. PD-L1 expression in immune cells is 19.9%. Immune cell expression and the number of expressing immune cells correlate with spontaneous necrosis. Immune cell expression and the number of expressing immune cells are increased in high-grade meningiomas. PD-1 expression in immune cells is 9.0%, and this correlates with brain invasion.Conclusions: With these data, it was observed that the expression of immune checkpoint molecules PD-L1, PD-1 increased especially in high-grade meningiomas. It may be the subject of research that these molecules may be targets of immunotherapy in the treatment of meningiomas.

Keywords

PD-L1, PD-1, meningioma, immunotherapy, immune checkpoint

First Page

735

Last Page

743

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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