•  
  •  
 

Turkish Journal of Medical Sciences

Author ORCID Identifier

MUSA SALMANOĞLU: 0000-0002-5050-531X

İRFAN KÜÇÜK: 0000-0001-7449-8276

BAŞAK ÇAKIR GÜNEY: 0000-0003-2389-2833

BETÜL DOĞANTEKİN: 0000-0002-4023-6013

NURGÜL TÜKEL: 0000-0002-0499-0078

ZELİHA SERİNDAĞ: 0000-0002-5919-8643

HABİP YILMAZ: 0000-0002-5138-3940

MUSTAFA KAPLAN: 0000-0002-0354-4762

DOI

10.55730/1300-0144.5841

Abstract

Background/aim: In ulcerative colitis (UC), serum vascular endothelial growth factor (sVEGF) concentrations are elevated and there are conflicting results about serum calprotectin (SCP) and sVEGF as biomarkers. We aimed to evaluate the relationship between sVEGF and SCP levels in UC patients, and the associations of these molecules and the phenotypes of UC. Materials and methods: This prospective case-control study included 60 UC patients and 30 healthy controls. The Mayo Clinical Scoring System (MCS) was used for patients' clinical and endoscopic features (MES). Truelove and Richard's method was applied to the histology activity index (HAI). The human VEGF (Cat.E0080Hu) and the human calprotectin (Cat.E4010Hu) kits were used for the enzyme-linked immunosorbent assay (ELISA) of sVEGF and SCP.Results: The median sVEGF and SCP levels were higher in the patients compared to healthy controls [2139 ng/L (126–5783) vs 888 ng/L (715–5270), p=0.002 and 932 ng/L (99–2648) vs 80 ng/L (56–920), p<0.001, respectively]. There was a strong correlation between the SCP and sVEGF values (rho=0.819, p<0.001). The MCS, MES, and HAI values were positively correlated to sVEGF and SCP concentrations.Conclusion : Serum VEGF and SCP can be valuable auxiliary biomarkers for UC.

Keywords

Calprotectin, Ulcerative colitis, VEGF

First Page

718

Last Page

726

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Download

Share

COinS