•  
  •  
 

Turkish Journal of Medical Sciences

DOI

10.55730/1300-0144.5767

Abstract

The aim of this study is to evaluate the baseline F18-FDG PET/CT findings of individuals diagnosed with giant cellarteritis (GCA) and to explore its association with clinical findings and classification criteria.Materials and methods: We analysed data from patients who underwent F18-FDG PET/CT scans to investigate large vessel (LV)involvement between 2010 and 2019. Only patients with a clinical diagnosis of GCA and at least 6 months of follow-up were included.We compared initial clinical features and laboratory findings based on the presence of LV vasculitis on PET/CT and the maximumstandard uptake value (SUVmax) of vascular territories.Results: Twenty-nine patients (median age at diagnosis: 70, F/M: 24/5) were included in the study. Among them, 21 patients (72.4%)presented with cranial symptoms, while 8 patients (27.5%) had isolated LV-GCA. Twenty-two patients (75.9%) met the ACR/EULAR2022 GCA classification criteria. LV vasculitis was detected on PET/CT in 23 patients (79.3%). A positive correlation was observedbetween SUVmax in the thoracic aorta and both CRP and ESR levels (r = 0.50, p = 0.026 and r = 0.63, p = 0.002, respectively). PET/CTpositive patients were found to be younger (p = 0.016) and more frequently female (p = 0.017). They also exhibited fewer headaches(56.5% vs. 100%, p = 0.04), experienced fewer flares during follow-up (p = 0.03), and had a lower cumulative glucocorticoid dose at the6th month (p = 0.036). Comparison of PET/CT-positive patients (n = 23) based on the fulfilment of the ACR/EULAR 2022 classificationcriteria revealed that patients who met these criteria were older (p = 0.02) and had significantly lower CRP levels at diagnosis (p = 0.02).Conclusion: The performance of F18-FDG PET/CT in diagnosing LV involvement in GCA is favourable, and the severity of FDGuptake in the vessel wall correlates with the acute phase response. Patients with extracranial involvement on PET/CT exhibit distinctfeatures, including a younger age and female predominance. Additionally, these patients appear to experience fewer relapses and requirelower doses of glucocorticoids. However, the clinical significance of PET/CT in patients who met ACR/EULAR classification criteria,predominantly consisting of patients with ischemic cranial symptoms, could not be determined in our study.

Keywords

Giant cell arteritis, large vessel vasculitis, positron emission tomography

First Page

69

Last Page

75

Download

Share

COinS