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Turkish Journal of Medical Sciences

DOI

10.55730/1300-0144.5773

Abstract

Extracorporeal blood purification (EBP) therapies have shown promise as potential rescue treatments for patientswith septic shock. However, precise evidence regarding their effectiveness is lacking. This case-control study aimed to evaluate the 28-day survival benefit of a resin cartridge-based EBP therapy compared to conventional therapies in patients with septic shock.Materials and methods: The study sample was collected retrospectively from the medical records of patients admitted to the intensivecare unit (ICU) between 2015 and 2020. The study included patients with septic shock aged ≥18 years who had ICU stays >96 h andexcluded those lost to follow-up by 28 days or readmitted. First, 28-day survival was compared between EBP patients and 1:1 matchedconventionally treated controls. Second, the EBP patients were evaluated for clinical and laboratory improvements within 72 h of EBPtherapy.Results: Of 3742 patients, 391 were included in this study, of whom 129 received EBP therapy and had a 28-day survival rate of 44%,compared to 262 matched controls who received conventional therapy alone and had a survival rate of 33% (p = 0.001, log-rank =0.05, number needed to treat = 8, and odds ratio = 1.7). After receiving EBP therapy for 72 h, improvements were observed in theSequential Organ Failure Assessment scores (p < 0.05), shock indices (p < 0.05), partial pressure of oxygen in the arterial blood to the fractionof inspiratory oxygen concentration ratios (p < 0.001), vasopressor requirements (p < 0.001), pH (p < 0.05), lactate levels (p < 0.001), andC-reactive protein levels (p < 0.05).Conclusion: The findings suggest that administering resin cartridge-based EBP therapy to patients with septic shock may improve theirsurvival compared to conventional therapies.

Keywords

Blood purification, critical care, extracorporeal therapy, sepsis, septic shock

First Page

128

Last Page

135

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