Turkish Journal of Medical Sciences
DOI
10.55730/1300-0144.5520
Abstract
Background/aim: Data on antibody response following COVID-19 in kidney transplant recipients is scarce. This crosssectional study aims to investigate the antibody response to COVID-19 among kidney transplant recipients. Materials and methods: We recruited 46 kidney transplant recipients with RT-PCR-confirmed COVID-19 and 45 recipients without COVID-19 history. We also constructed two control groups (COVID-19 positive and negative) from a historical cohort of healthcare workers. We used age and sex-based propensity score matching to select the eligible subjects to the control groups. We measured the SARS-CoV-2 IgG levels quantitatively using the Abbott ARCHITECT system. An antibody level above 1.4 S/C was defined as positivity. Results: Transplant recipients with COVID-19 had a higher BMI, and COVID-19 history in a household member was more common than that of the transplant recipient without COVID-19. IgG seropositivity rate (69.6% vs. 78.3%, p = 0.238) and the median IgG level (3.28 [IQR: 0.80-5.85] vs. 4.59 [IQR: 1.61-6.06], p = 0.499) were similar in COVID-19-positive transplant recipients and controls. Kidney transplant recipients who had a longer duration between RT-PCR and antibody testing had lower antibody levels (r = -0.532, p < 0.001). Conclusion: At the early post-COVID-19 period, kidney transplant recipients have a similar antibody response to controls. However, these patients' antibody levels and immunity should be closely monitored in the long term.
First Page
1754
Last Page
1761
Recommended Citation
DİNCER, MEVLÜT TAMER; EREN, NECMİ; MURT, AHMET; YILDIZ, NURİYE; ÖZCAN, ŞEYDA GÜL; ERGÜL, METİN; BEK, SİBEL GÖKÇAY; ATLI, ZEYNEP; TRABULUS, SİNAN; DERVİŞOĞLU, ERKAN; DOĞANAY, HAMDİ LEVENT; and SEYAHİ, NURHAN
(2022)
"A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection,"
Turkish Journal of Medical Sciences: Vol. 52:
No.
6, Article 3.
https://doi.org/10.55730/1300-0144.5520
Available at:
https://journals.tubitak.gov.tr/medical/vol52/iss6/3