Turkish Journal of Medical Sciences
Cerebrospinal fluid level of neurofilament light chain is associated with increased disease activity in neuro-Behçet's disease
Background/aim: Clinical exacerbations characterized with neurological symptoms are observed in around 10% of Behçet's disease (BD) patients and may culminate in severe disability. Although certain immunological factors have been associated with disease activity in neuro-Behçet's disease (NBD), biomarkers for monitoring the clinical outcome of NBD have not been properly investigated. Materials and methods: Levels of neurofilament light chain (NFL), homeobox protein Hox-B3 (HoxB3), and YKL-40 were measured in cerebrospinal fluid (CSF) samples of 23 parenchymal (n = 16) and nonparenchymal (n = 7) NBD patients obtained during NBD attacks by ELISA. Parameters of clinical progression and outcome were assessed for an average follow-up period of 3.9 ± 1.3 years. Results: Parenchymal NBD patients showed elevated CSF levels of NFL, HoxB3, and YKL-40 as compared to nonparenchymal patients. NBD patients showing an increase in modified Rankin score (mRS) values during follow-up had significantly higher CSF NFL levels. Patients with relatively lower CSF NFL levels (
Neurofilament light, hoxB3, ykl-40, neuro-Behçet, prognosis
KARAASLAN, ZERRİN; ŞANLI, ELİF; KAHRAMAN, ÖZLEM TİMİRCİ; YILMAZ, VUSLAT; AKBAYIR, ECE; KORAL, GİZEM; İÇÖZ, SEMA; GÜNDÜZ, TUNCAY; KÜÇÜKALİ, CEM İSMAİL; KÜRTÜNCÜ, MURAT; and TÜZÜN, ERDEM
"Cerebrospinal fluid level of neurofilament light chain is associated with increased disease activity in neuro-Behçet's disease,"
Turkish Journal of Medical Sciences: Vol. 52:
4, Article 47.
Available at: https://journals.tubitak.gov.tr/medical/vol52/iss4/47