Turkish Journal of Medical Sciences
DOI
10.55730/1300-0144.5405
Abstract
Background/aim: Data on the presence and extent of cardiovascular disease (CVD) risk in primary hyperparathyroidism (PHPT) are conflicting. In our study, we aimed to investigate the increased CVD risk in patients with PHPT by carotid intima-media thickness (CIMT), epicardial adipose tissue (EAT) thickness, and serum levels of endocan and nesfatin-1. Materials and methods: Patients with PHPT (n = 44) and age- and sex-matched healthy control subjects (n = 40) were enrolled in this study. Demographic data of the participants were questioned. Serum endocan and nesfatin-1 concentrations were assessed using commercially available ELISA kits. Noninvasive measurements of CIMT and EAT thickness were made with high-resolution ultrasonography and B-mode echocardiography. Results: There was no statistically significant difference in serum endocan and nesfatin-1 levels and EAT thickness in the PHPT group compared to controls. CIMT was statistically significantly higher in the PHPT group compared to controls (p = 0.001). A negative correlation was found between PTH and low-density lipoprotein cholesterol level (p = 0.001) but no significant relationship was found between other parameters. Conclusion: We found that CIMT is increased in patients with PHPT and consequently, CVD risk is high in these patients. More comprehensive studies are needed to identify other markers that predict increased CVD risk in patients with PHPT.
Keywords
Primary hyperparathyroidism, carotid intima media thickness, epicardial adipose tissue thickness, endocan, nesfatin-1, cardiovascular disease risk
First Page
1033
Last Page
1040
Recommended Citation
KOCABAŞ, MUHAMMET; ALSANCAK, YAKUP; CAN, MUSTAFA; ÇORDAN, İLKER; BURGUCU, HATİCE ÇALIŞKAN; KARAKÖSE, MELİA; YERLİKAYA, FATMA HÜMEYRA; KULAKSIZOĞLU, MUSTAFA; and KARAKURT, FERİDUN
(2022)
"Evaluation of subclinical cardiovascular disease by carotid intima media thickness, epicardial adipose tissue thickness, serum endocan, and nesfatin-1 levels in patients with primary hyperparathyroidism,"
Turkish Journal of Medical Sciences: Vol. 52:
No.
4, Article 20.
https://doi.org/10.55730/1300-0144.5405
Available at:
https://journals.tubitak.gov.tr/medical/vol52/iss4/20