An evaluation of the results of convalescent plasma therapy applied to pregnant womendiagnosed as COVID-19- positive in a pandemic center: A prospective cohort study

Authors

SEYİT AHMET EROL
ATAKAN TANAÇAN
HAKAN APAYDIN
ŞULE GÖNCÜ AYHAN
DENİZ OLUKLU
DERYA UYAN HENDEM
SERPİL ÜNLÜ
ABDULSAMET ERDEN
ÖZLEM MORALOĞLU TEKİN
AHMET OMMA
İHSAN ATEŞ
ORHAN KÜÇÜKŞAHİN
DİLEK ŞAHİN

DOI

10.55730/1300-0144.5346

Abstract

Background/aim: Convalescent plasma (CP) might be an additional treatment modality in COVID-19. The aim of this study was to compare CP-related clinical characteristics and perinatal outcomes in pregnant women with mild or moderate-severe COVID-19. Materials and methods: This prospective cohort study included 36 pregnant women (12 mild and 24 moderate-severe), who underwent CP therapy. The CP obtained from recently recovered donors was transfused to patients together with maximum supportive care and antiviral agents. The groups were then compared in respect of clinical characteristics, laboratory parameters, obstetric complications, and neonatal outcomes. Results: Significant differences were determined between the groups in respect of systemic corticosteroids in COVID-19 treatment (41.7%, 87.5%, p = 0.004), oxygen (O2) support (0%, 91.7%, p < 0.001), chest imaging (41.7%, 58.3%, p = 0.02), intensive care unit admission (0%, 20.8%, p = 0.03) and length of hospitalization (5.5 versus 9.5 days, p < 0.001). The O2 saturation levels before and after administration of CP were significantly lower in the moderate-severe COVID-19 group (p < 0.05). The O2 therapy time before and after administration of CP and total O2 therapy time were significantly lower in the mild COVID-19 group (p < 0.05). Platelet, plateletcrit and lymphocyte counts were significantly higher in both the mild and moderate-severe COVID-19 groups after treatment compared to the pretreatment values (p < 0.05). Conclusion: Although data on the results of CP treatment in pregnant women are somewhat limited, it has been suggested that early CP treatment may be associated with improvements in laboratory and ventilatory parameters in pregnant women with mild and moderatesevere COVID-19. Nevertheless, there is a need for further, randomized controlled studies on this subject with the inclusion of greater numbers of patients.

Keywords

Clinical characteristics, convalescent plasma, COVID-19, laboratory parameters, pregnancy outcomes

First Page

554

Last Page

564

Recommended Citation

EROL, SEYİT AHMET; TANAÇAN, ATAKAN; APAYDIN, HAKAN; AYHAN, ŞULE GÖNCÜ; OLUKLU, DENİZ; HENDEM, DERYA UYAN; ÜNLÜ, SERPİL; ERDEN, ABDULSAMET; TEKİN, ÖZLEM MORALOĞLU; OMMA, AHMET; ATEŞ, İHSAN; KÜÇÜKŞAHİN, ORHAN; and ŞAHİN, DİLEK (2022) "An evaluation of the results of convalescent plasma therapy applied to pregnant womendiagnosed as COVID-19- positive in a pandemic center: A prospective cohort study," Turkish Journal of Medical Sciences: Vol. 52: No. 3, Article 4. https://doi.org/10.55730/1300-0144.5346
Available at: https://journals.tubitak.gov.tr/medical/vol52/iss3/4