Turkish Journal of Medical Sciences
Hidden threat in familial Mediterranean fever: subclinical inflammation, oxidative stress and their relationship with vitamin D status
Background/aim: Vitamin D levels have been investigated in children with familial Mediterranean fever (FMF), but the relationship between vitamin D status and inflammation/oxidative stress indicators could not be clearly demonstrated. This study aimed to investi- gate the relationship between subclinical inflammation/oxidative stress and vitamin D status in children with FMF during an attack-free period. Materials and methods: In the cross-sectional study, ninety children with FMF in the attack-free period and 30 healthy children were included. Patients were grouped according to their vitamin D status (< 20, 20-29, and 30-100 ng/mL). The groups were compared in terms of pentraxin 3 (PTX-3), total oxidant status (TOS), and total antioxidant status (TAS). Multivariable linear regression analysis was performed to identify factors associated with vitamin D status. Results: PTX-3 levels were significantly higher in patients with vitamin D insufficiency (20-29 ng/mL) than in the group with vitamin D sufficient (30-100 ng/mL). Patients with vitamin D deficiency (< 20 ng/mL) had higher TOS. A strong negative correlation was ob- served between vitamin D levels and TOS (p = 0.003). Subclinical inflammation (PTX-3 ≥ 0.640) and high TOS levels were negatively associated with vitamin D levels. Conclusion: Subclinical inflammation and oxidative stress were negatively associated with vitamin D levels in patients with FMF dur- ing an attack-free period. Sufficient vitamin D levels are important in fighting subclinical inflammation and oxidative stress in children with FMF.
Familial Mediterranean fever, inflammation, vitamin D, oxidative stress
ALESH, MHD BOSHR; KETİ, DİDEM BARLAK; KISAARSLAN, AYŞENUR PAÇ; MUHTAROĞLU, SABAHATTİN; and TAŞKIN, SEMA NUR
"Hidden threat in familial Mediterranean fever: subclinical inflammation, oxidative stress and their relationship with vitamin D status,"
Turkish Journal of Medical Sciences: Vol. 52:
1, Article 8.
Available at: https://journals.tubitak.gov.tr/medical/vol52/iss1/8