Turkish Journal of Medical Sciences
Abstract
Background/aim: This study was conducted to elucidate the effects of lutein/zeaxanthin isomers (L/Zi) on lipid metabolism, oxidative stress, NF-ΚB/Nrf2 pathways, and synaptic plasticity proteins in trained rats. Materials and methods: Wistar rats were distributed into four groups: 1) control, 2) L/Zi: rats received L/Zi at the dose of 100 mg/kg by oral gavage, 3) exercise, 4) exercise+L/Zi: rats exercised and received L/Zi (100 mg/kg) by oral gavage. The duration of the study was eight weeks. Results: Exercise combined with L/Zi reduced lipid peroxidation and improved antioxidant enzyme activities of muscle and cerebral cortex in rats (p < 0.001). In the Exercise + L/Zi group, muscle and cerebral cortex Nrf2 and HO-1 levels increased, while NF-ΚB levels decreased (p
DOI
10.3906/sag-2101-264
Keywords
Lutein, zeaxanthin, exercise, oxidative stress, synaptic proteins
First Page
2167
Last Page
2176
Recommended Citation
ORHAN, C, ERTEN, F, ER, B, TUZCU, M, ŞAHİN, N, KURŞUN, Ö. E, Juturu, V, & ŞAHİN, K (2021). Lutein/zeaxanthin isomers regulate neurotrophic factors and synaptic plasticity intrained rats. Turkish Journal of Medical Sciences 51 (4): 2167-2176. https://doi.org/10.3906/sag-2101-264
