The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity

Authors

HATİCE SARAÇOĞLU
ESER KILIÇ
ESRA DEMİRCİ

Abstract

Background/aim: Attention deficit and hyperactivity disorder (ADHD) is a widespread neurodevelopmental disorder that begins in childhood and has negative consequences throughout adult life. The etiology and pathogenesis of ADHD are still unclear. Tau protein is a soluble microtubule-related protein expressed by neurons and localized in the cytoplasm as well as axons. Tau protein provides stability of microtubule in two ways: phosphorylation and isoforms. The excessive phosphorylation of Tau separates the protein from the microtubule, thus making it unstable. In this study, we aimed to investigate whether there is a relationship between serum Tau protein and phospho Tau (p-Tau181) levels and ADHD occurrence. Materials and methods: This study included 26 male children aged 7-12 years with newly diagnosed ADHD, who had previously not used any medication for ADHD, and 26 male healthy children. Serum Tau and p-Tau181 concentrations were performed by enzymelinked immunosorbent assay (ELISA). Results: In patients, the Tau levels were not significantly different from those of the controls; the p-Tau181 levels were significantly higher than those of the controls. Conclusion: We concluded that high p-Tau181 might be associated with the progression of ADHD and cognitive changes in ADHD.

DOI

10.3906/sag-2012-198

Keywords

Attention deficit and hyperactivity disorder, Tau, phospho Tau

First Page

2107

Last Page

2111

Recommended Citation

SARAÇOĞLU, HATİCE; KILIÇ, ESER; and DEMİRCİ, ESRA (2021) "The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity," Turkish Journal of Medical Sciences: Vol. 51: No. 4, Article 67. https://doi.org/10.3906/sag-2012-198
Available at: https://journals.tubitak.gov.tr/medical/vol51/iss4/67