Turkish Journal of Medical Sciences
The contribution of postnatal steroid administration to early brain damage in pretermbabies with bronchopulmonary dysplasia
Background/aim: Postnatal corticosteroids are commonly used to treat bronchopulmonary dysplasia (BPD). We aimed to show whether S100 calcium-binding B (S100B), neuron-specific enolase (NSE), Tau protein or microtubule-associated protein tau (MAPT), and glial fibrillary acid protein (GFAP) levels would provide any evidence of early neurological damage in premature infants receiving postnatal low dose dexamethasone therapy for BPD treatment. Materials and methods: In this cohort study, 136 preterm infants diagnosed with BPD at ≤ 32 weeks of gestation formed the study group, and 64 preterm infants formed the control group. NSE, S100B, GFAP, and MAPT levels were first measured before the postnatal corticosteroid treatment in both the patient and the control group on the 28th day and, for a second time, after treatment termination in the patient group. Results: There were significant differences between the measured GFAP, MAPT, and NSE values of the BPD and control groups on the 28th day, whereas there was no significant difference between the measured S100B values of the two groups. There were a statistically significant difference between the NSE values measured on the 28th day and after the treatment within the BPD group, whereas no significant difference existed between the GFAP, MAPT, and S100B values. Conclusion: NSE levels, which indicate brain damage in the early period, increased in preterm babies with BPD who had been administered postnatal dexamethasone.
Bronchopulmonary dysplasia, neuron-specific enolase, microtubule-associated proteins, glial fibrillary acidic protein, S100 proteins
ERTUĞRUL, SABAHATTİN; DARAKCİ, SAVAŞ MERT; KAPLAN, İBRAHİM; YOLBAŞ, İLYAS; DEGER, İBRAHİM; YILMAZ, SİBEL TANRIVERDİ; and AKTAŞ, ŞERAFETTİN
"The contribution of postnatal steroid administration to early brain damage in pretermbabies with bronchopulmonary dysplasia,"
Turkish Journal of Medical Sciences: Vol. 51:
4, Article 42.
Available at: https://journals.tubitak.gov.tr/medical/vol51/iss4/42