Background/aim: Sleep deprivation disrupts prepulse inhibition of acoustic startle reflex and can be used to mimic psychosis in experimental animals. On the other hand, it is also a model for other disorders of sensory processing, including migraine. This study aims to assess the effects of sodium valproate, a drug that is used in a variety of neuropsychiatric disorders, on normal and disrupted sensorimotor gating in rats. Materials and methods: Sixty-two Wistar albino rats were randomly distributed into 8 groups. Subchronic and intraperitoneal sodium valproate were administrated to the sleep-deprived and nonsleep-deprived rats by either 50-100 or 200 mg/kg/day. Prepulse inhibition test and locomotor activity test were performed. Sleep deprivation induced by the modified multiple platform method. Results: Sleep deprivation impaired prepulse inhibition, decreased startle amplitude, and increased locomotor activity. Sodium valproate did not significantly alter prepulse inhibition and locomotor activity in nonsleep-deprived and sleep-deprived groups. On the other hand, all doses decreased locomotor activity in drug-treated groups, and low dose improved sensorimotor gating and startle amplitude after sleep deprivation. Conclusion: Low-dose sodium valproate improves sleep deprivation-disrupted sensorimotor gating, and this finding may rationalize the use of sodium valproate in psychotic states and other sensory processing disorders. Dose-dependent effects of sodium valproate on sensorimotor gating should be investigated in detail.
Sleep deprivation, sodium valproate, prepulse inhibition, sensorimotor gating, psychosis, rat
TEKİN, MUHAMMET; YERTUTANOL, FATMA DUYGU KAYA; ÇEVRELİ, BURCU; ÖZDOĞRU, ASİL ALİ; KULAKSIZ, HAMZA; and UZBAY, İSMAİL TAYFUN
"Sodium valproate improves sensorimotor gating deficit induced by sleep deprivation atlow doses,"
Turkish Journal of Medical Sciences: Vol. 51:
3, Article 77.
Available at: https://journals.tubitak.gov.tr/medical/vol51/iss3/77