Background/aim: To evaluate the impact of treatment with sodium-glucose co-transporter-2 (SGLT2) Inhibitors on quality of life (QoL), sleep quality (SQ), and anxiety levels in patients with Type 2 diabetes mellitus (T2DM). Materials and methods: Ninety-seven patients with type 2 diabetes admitted to tertiary care hospital diabetes clinic were included. Fifty patients were randomized to receive SGLT2 inhibitors in addition to baseline treatment (Group A), 47 subjects continued with their baseline treatment or were added other medications as needed (Group B). Thirty healthy controls (HC) were recruited (Group C). All groups were subjected to the Turkish version of Short Form-36 (SF-36), Pittsburgh Sleep Quality (PSQ), and Beck Anxiety Inventory (BAI) scales both at baseline and final visit. Results: Physical function, emotional role limitation, vitality, mental health, pain, general health perception scores of SF-36 were significantly improved in Group A, at the end of the follow-up period. There was no significant change in terms of PSQ, BAI scores, and hypoglycaemia documented in all groups. The intervention-related change in HbA1c level, body weight, and body mass index were significantly higher in Group A. Conclusion: The QoL was improved in people with diabetes who were taking SGLT2 inhibitors. This may be explained by weight loss observed in participants.
Anxiety, sleep quality, quality of life, sodium-glucose co-transporter 2 inhibitor
ŞAHİN, SERDAR; HALİLOĞLU, ÖZLEM; KORKMAZ, ÖZGE POLAT; DURCAN, EMRE; ŞAHİN, HÜMEYRA REKALI; YUMUK, VOLKAN DEMİRHAN; DAMCI, TANER; İLKOVA, HASAN MAHMUT; and SİVA, ZEYNEP OŞAR
"Does treatment with sodium-glucose co-transporter-2 inhibitors have an effect on sleepquality, quality of life, and anxiety levels in people with Type 2 diabetes mellitus?,"
Turkish Journal of Medical Sciences: Vol. 51:
2, Article 45.
Available at: https://journals.tubitak.gov.tr/medical/vol51/iss2/45