Background/aim: ß1-selective beta-blockers (BBs) are sympatholytic agents, and discerning their effects on bone health would be of great importance. This study aimed to investigate the influence of ß1-selective BBs on bone mineral density (BMD) and fracture risk. Materials and methods: This study included postmenopausal women who used ß1-selective BBs (BB group) and control group. Sociodemographic characteristics, BMD and previous fragility fractures were recorded. Additionally, the 10-year probability of a major osteoporotic and hip fracture was calculated using the fracture risk assessment tool (FRAX). Results: A total of 60 participants were included in the study. L1-4 and L2-4 BMD values were significantly higher in BB group than control group (P = 0.015 and P = 0.025, respectively). Moreover, T-scores of lumbar and femur total were significantly higher in the BB group. Two patients in BB and 6 patients in control group had previous fragility fracture. No statistically significant intergroup difference was noted regarding FRAX. Conclusion: Based on our results, ß1-selective BB usage was associated with higher BMD at the lumbar region in postmenopausal women.
Adrenergic beta-antagonists, postmenopause, bone mineral density
KELEŞ, BETÜL YAVUZ; VURAL, MELTEM; ÖNDER, BURCU; and ÖNEŞ, KADRİYE
"Evaluation of the effects of ß1-selective beta-blockers on bone mineral density and fracture risk in postmenopausal women,"
Turkish Journal of Medical Sciences: Vol. 50:
4, Article 46.
Available at: https://journals.tubitak.gov.tr/medical/vol50/iss4/46