Turkish Journal of Medical Sciences
Effect of metformin and detorsion treatment on serum anti-Müllerian hormonelevels and ovarian histopathology in a rat ovarian torsion model
Background/aim: Adnexal torsion is a common gynaecological emergency, and considered to be a problem mostly in reproductive-age women. To evaluate the effect of metformin and detorsion treatment on reducing ovarian reserve in an ovarian torsion model. Materials and methods: Twenty-four nonpregnant, Wistar Hannover rats were included in the study. Animals were divided into 3 groups: the control group, the detorsion only group, and the metformin + detorsion group. The first group received only laparotomy. In the second group, ovaries were fixed to the abdominal wall after performing 360° ovarian torsion, followed by detorsion after a 3-h period of ischemia. The third group underwent the same torsion and detorsion procedures as the second group, and received 50 mg/kg metformin by gavage for 14 days. Ovarian damage scores, follicle counts, and AMH levels were evaluated. Results: The total damage score was significantly increased in the detorsion only group compared to the metformin+detorsion and control groups. Pre-operative/post-operative AMH decreases were statistically significant in negative direction in the detorsion only group when compared to the metformin+detorsion and control groups (P = 0.001). Conclusion: Metformin+detorsion treatment may be effective in protecting the ovarian reserve after ovarian torsion.
anti-Müllerian hormone, detorsion, metformin, ovarian reserve, ovarian torsion
KARAKAŞ, SEMA; KAYA, CİHAN; GÜRASLAN, HAKAN; SAKIZ, DAMLANUR; ÇAYPINAR, SEMA SÜZEN; CENGİZ, HÜSEYİN; EKİN, MURAT; and YAŞAR, LEVENT
"Effect of metformin and detorsion treatment on serum anti-Müllerian hormonelevels and ovarian histopathology in a rat ovarian torsion model,"
Turkish Journal of Medical Sciences: Vol. 50:
2, Article 24.
Available at: https://journals.tubitak.gov.tr/medical/vol50/iss2/24