Factors associated with glomerular filtration rate variation in primary hyperparathyroidism after parathyroidectomy

Authors

MUSTAFA ÇALIŞKAN
MUHAMMED KIZILGÜL
SELVİHAN BEYSEL
BEKİR UÇAN
FATİH ALPER AKCAN
MÜMTAZ TAKIR
MUSTAFA ÖZBEK
ERMAN ÇAKAL

DOI

10.3906/sag-1806-181

Abstract

Background/aim: Prolonged hypercalcemia impairs renal function, and a reduced glomerular filtration rate (GFR) is typical in advanced primary hyperparathyroidism (PHPT). There are scarce data related to predictors of renal impairment in patients with PHPT. Hence, we aimed to evaluate changes in kidney function in PHPT patients after parathyroidectomy (PTX) and identify factors associated with GFR variation in these patients.Materials and methods: One hundred and twenty-five patients with PHPT who underwent surgery between 2012 and 2014 were enrolled in the study. Patients were divided into two groups according to GFR values: patients whose GFR was lower than 60 mL/min/1.73 m2 and higher than 60 mL/min/1.73 m2. Demographic and laboratory parameters were compared before and 6 months after parathyroidectomy.Results: Prevalence of antihypertensive drug users and patients with renal cysts and parathormone (PTH) and alkaline phosphatase levels were higher in patients with GFR of ≥60 than in GFR of

Keywords

Primary hyperparathyroidism, predictors, renal failure, parathyroidectomy

First Page

295

Last Page

300

Recommended Citation

ÇALIŞKAN, MUSTAFA; KIZILGÜL, MUHAMMED; BEYSEL, SELVİHAN; UÇAN, BEKİR; AKCAN, FATİH ALPER; TAKIR, MÜMTAZ; ÖZBEK, MUSTAFA; and ÇAKAL, ERMAN (2019) "Factors associated with glomerular filtration rate variation in primary hyperparathyroidism after parathyroidectomy," Turkish Journal of Medical Sciences: Vol. 49: No. 1, Article 44. https://doi.org/10.3906/sag-1806-181
Available at: https://journals.tubitak.gov.tr/medical/vol49/iss1/44