Turkish Journal of Medical Sciences
Comparison of reference systems in the assessment of age-related serum immunoglobulin levels in pediatric patients
Ig level assessment is frequently used in the diagnosis and follow-up of immunodeficiency, as well as in studies investigating the prevalence of low serum Ig level in specific diseases.Material and methods: Patients who underwent Ig testing in the inpatient and outpatient clinics of our hospital in the years 2010-2016 were included. The Ig levels of the patients were assessed separately according to two reference systems commonly used in Turkey and another reference system used in the USA.Results: A total of 20,138 patients (57.6% male) were included in the study. The median age of the patients was 55.7 months (interquartile range: 23.1-96.7). According to the reference intervals determined by Tezcan et al., 30.6% of the patients were deficient in one or more Ig values. This rate was 4 times higher than those based on the reference intervals determined by Aksu et al. (7.7%) and those in the Nelson Textbook of Pediatrics (6.8%). We also determined that the frequency of low Ig levels with three reference systems.Conclusion: In this study, we found that the rates of low Ig level in a group of pediatric patients differed significantly when evaluated using three different reference systems for age-related serum Ig levels
Children, reference system, serum immunoglobulin levels
ÇELİK, İLKNUR KÜLHAŞ; CİVELEK, ERSOY; METİN, AYŞE; GİNİŞ, TAYFUR; TOYRAN, MÜGE; MISIRLIOĞLU, EMİNE DİBEK; and KOCABAŞ, CAN NACİ
"Comparison of reference systems in the assessment of age-related serum immunoglobulin levels in pediatric patients,"
Turkish Journal of Medical Sciences: Vol. 49:
1, Article 22.
Available at: https://journals.tubitak.gov.tr/medical/vol49/iss1/22