Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease

Authors

GÜL SEMA YILDIRAN KESKİN
ÖZANT HELVACI
ÇAĞRI YAYLA
ÖZGE TUĞÇE PAŞAOĞLU
ÇAĞLAR KESKİN
SELİM TURGAY ARINSOY
ÜLVER DERİCİ

DOI

10.3906/sag-1804-169

Abstract

We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery. Results: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = -0.674 and r = -0.471, respectively). Conclusion: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.

Keywords

YKL-40, CKD, hemodialysis, atherosclerosis, endothelial dysfunction

First Page

139

Last Page

146

Recommended Citation

KESKİN, GÜL SEMA YILDIRAN; HELVACI, ÖZANT; YAYLA, ÇAĞRI; PAŞAOĞLU, ÖZGE TUĞÇE; KESKİN, ÇAĞLAR; ARINSOY, SELİM TURGAY; and DERİCİ, ÜLVER (2019) "Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease," Turkish Journal of Medical Sciences: Vol. 49: No. 1, Article 21. https://doi.org/10.3906/sag-1804-169
Available at: https://journals.tubitak.gov.tr/medical/vol49/iss1/21