Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease

Authors

GÜL SEMA YILDIRAN KESKİN
ÖZANT HELVACI
ÇAĞRI YAYLA
ÖZGE TUĞÇE PAŞAOĞLU
ÇAĞLAR KESKİN
SELİM TURGAY ARINSOY
ÜLVER DERİCİ

Abstract

We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery. Results: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = -0.674 and r = -0.471, respectively). Conclusion: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.

DOI

10.3906/sag-1804-169

Keywords

YKL-40, CKD, hemodialysis, atherosclerosis, endothelial dysfunction

First Page

139

Last Page

146

Recommended Citation

KESKİN, GÜL SEMA YILDIRAN; HELVACI, ÖZANT; YAYLA, ÇAĞRI; PAŞAOĞLU, ÖZGE TUĞÇE; KESKİN, ÇAĞLAR; ARINSOY, SELİM TURGAY; and DERİCİ, ÜLVER (2019) "Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease," Turkish Journal of Medical Sciences: Vol. 49: No. 1, Article 21. https://doi.org/10.3906/sag-1804-169
Available at: https://journals.tubitak.gov.tr/medical/vol49/iss1/21