Concordance of immunohistochemistry between core needle biopsy and surgical resection of breast cancer

Authors

FARUK ERDEM KOMBAK
HÜLYA ŞAHİN
HANDE MOLLAMEMİŞOĞLU
İDRİS ÖNEM
HANDAN KAYA
ONUR BUĞDAYCI
MUSTAFA ERKİN ARIBAL

DOI

10.3906/sag-1702-152

Abstract

Background/aim: The purpose of this study was to evaluate the concordance of immunohistochemical (IHC) parameters of breast lesions between the core needle biopsy (CNB) and the surgical resection specimen. Materials and methods: CNB and resection specimens of female patients were retrospectively analyzed. ER, PR, HER-2, and Ki-67 parameters were compared for each patient. A total of 284 cases were assessed. Forty-one and 48 cases were excluded from the HER-2 and Ki-67 examinations, respectively, because the CNBs did not allow for IHC. Results: Concordance rates were 93.3% for ER, 89.4% for PR, 90.1% for HER-2, and 80.9% for Ki-67.Conclusion: CNB is accurate for the evaluation of the surrogate molecular profile of invasive breast cancer despite the heterogeneity of tumors.

Keywords

Breast cancer, image-guided biopsy, immunohistochemistry, Ki-67, hormone receptors, c-erb-B2

First Page

1791

Last Page

1796

Recommended Citation

KOMBAK, FARUK ERDEM; ŞAHİN, HÜLYA; MOLLAMEMİŞOĞLU, HANDE; ÖNEM, İDRİS; KAYA, HANDAN; BUĞDAYCI, ONUR; and ARIBAL, MUSTAFA ERKİN (2017) "Concordance of immunohistochemistry between core needle biopsy and surgical resection of breast cancer," Turkish Journal of Medical Sciences: Vol. 47: No. 6, Article 19. https://doi.org/10.3906/sag-1702-152
Available at: https://journals.tubitak.gov.tr/medical/vol47/iss6/19