Risk factors for colistin-associated nephrotoxicity and mortality in critically ill patients

Authors

HÜSEYİN ÖZKARAKAŞ
IŞIL KÖSE
ÇİLER ZİNCİRCİOĞLU
SİBEL ERSAN
GÜRSEL ERSAN
NİMET ŞENOĞLU
ŞÜKRAN KÖSE
RIZA HAKAN ERBAY

DOI

10.3906/sag-1604-60

Abstract

Background/aim: Colistin is gaining popularity against multidrug-resistant bacteria. The primary concern with colistin is its nephrotoxicity (NT). The aim of this study was to evaluate the incidence and risk factors for NT and to evaluate the risk factors for mortality in the toxicity group. Materials and methods: NT was defined according to the RIFLE criteria. Data of patients who did or did not develop NT were compared. Positive and negative predictive values, risk ratio, and correlation coefficients were calculated. Results: NT was seen in 39 patients (70%). Hypoalbuminemia, old age, and the use of vasopressors (VPs) were associated with NT. The use of VPs had the highest positive predictive value, while age had the highest negative predictive value and risk ratio. The only variable that was associated with mortality in the toxicity group was VP use. Conclusion: Aging, hypoalbuminemia, and the use of VPs were shown to be risk factors for NT, while the last of these was the only significant risk factor for mortality in the toxicity group.

Keywords

Colistin, risk factors, nephrotoxicity, mortality

First Page

1165

Last Page

1172

Recommended Citation

ÖZKARAKAŞ, HÜSEYİN; KÖSE, IŞIL; ZİNCİRCİOĞLU, ÇİLER; ERSAN, SİBEL; ERSAN, GÜRSEL; ŞENOĞLU, NİMET; KÖSE, ŞÜKRAN; and ERBAY, RIZA HAKAN (2017) "Risk factors for colistin-associated nephrotoxicity and mortality in critically ill patients," Turkish Journal of Medical Sciences: Vol. 47: No. 4, Article 18. https://doi.org/10.3906/sag-1604-60
Available at: https://journals.tubitak.gov.tr/medical/vol47/iss4/18