Turkish Journal of Medical Sciences
Abstract
Background/aim: Platelet-rich plasma (PRP) application has gained widespread interest for musculoskeletal injuries. Nonsteroidal antiinflammatory drugs are frequently used in sports medicine before and/or after PRP application. Our study seeks to determine whether serum levels of platelet-derived growth factor-AB (PDGF-AB) and vascular endothelial growth factor (VEGF) levels of PRP would be affected by nonsteroidal antiinflammatory drugs. Materials and methods: Two different final concentrations of diclofenac (0.5 6mu;g mL-1 and 2.5 6mu;g mL-1), meloxicam (0.8 μg mL-1 and 2.0 μg mL-1), and acetylsalicylic acid (final concentration 450 μm) were obtained in separate tubes with PRPs prepared from 20 healthy male volunteers. Medicine-free PRP was the control group. Growth factors were measured using ELISA. Results: PDGF-AB and VEGF serum levels did not change with diclofenac, meloxicam, or acetylsalicylic acid addition. PDGF-AB and VEGF serum levels correlated with each other. Conclusion: Diclofenac, meloxicam, and acetylsalicylic acid did not affect PDGF-AB and VEGF serum levels.
DOI
10.3906/sag-1602-60
Keywords
Platelet-rich plasma, PDGF-AB, VEGF, nonsteroidal antiinflammatory drugs
First Page
570
Last Page
576
Recommended Citation
UTKU, B, DÖNMEZ, G, ERİŞGEN, G, AKIN, Ş, DEMİREL, A. H, KORKUSUZ, F, & DORAL, M. N (2017). Meloxicam and diclofenac do not change VEGF and PDGF-ABserum levels of platelet-rich plasma. Turkish Journal of Medical Sciences 47 (2): 570-576. https://doi.org/10.3906/sag-1602-60
