Meloxicam and diclofenac do not change VEGF and PDGF-ABserum levels of platelet-rich plasma

Authors

BURKAY UTKU
GÜRHAN DÖNMEZ
GÜLRİZ ERİŞGEN
ŞENAY AKIN
ALİ HAYDAR DEMİREL
FEZA KORKUSUZ
MAHMUT NEDİM DORAL

DOI

10.3906/sag-1602-60

Abstract

Background/aim: Platelet-rich plasma (PRP) application has gained widespread interest for musculoskeletal injuries. Nonsteroidal antiinflammatory drugs are frequently used in sports medicine before and/or after PRP application. Our study seeks to determine whether serum levels of platelet-derived growth factor-AB (PDGF-AB) and vascular endothelial growth factor (VEGF) levels of PRP would be affected by nonsteroidal antiinflammatory drugs. Materials and methods: Two different final concentrations of diclofenac (0.5 6mu;g mL-1 and 2.5 6mu;g mL-1), meloxicam (0.8 μg mL-1 and 2.0 μg mL-1), and acetylsalicylic acid (final concentration 450 μm) were obtained in separate tubes with PRPs prepared from 20 healthy male volunteers. Medicine-free PRP was the control group. Growth factors were measured using ELISA. Results: PDGF-AB and VEGF serum levels did not change with diclofenac, meloxicam, or acetylsalicylic acid addition. PDGF-AB and VEGF serum levels correlated with each other. Conclusion: Diclofenac, meloxicam, and acetylsalicylic acid did not affect PDGF-AB and VEGF serum levels.

Keywords

Platelet-rich plasma, PDGF-AB, VEGF, nonsteroidal antiinflammatory drugs

First Page

570

Last Page

576

Recommended Citation

UTKU, BURKAY; DÖNMEZ, GÜRHAN; ERİŞGEN, GÜLRİZ; AKIN, ŞENAY; DEMİREL, ALİ HAYDAR; KORKUSUZ, FEZA; and DORAL, MAHMUT NEDİM (2017) "Meloxicam and diclofenac do not change VEGF and PDGF-ABserum levels of platelet-rich plasma," Turkish Journal of Medical Sciences: Vol. 47: No. 2, Article 29. https://doi.org/10.3906/sag-1602-60
Available at: https://journals.tubitak.gov.tr/medical/vol47/iss2/29