Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.
Bladder cancer, polymorphism, B7-H4 gene
ÖZGÖZ, ASUMAN; ŞAMLI, MURAT; DİNÇEL, DENİZ; ŞAHİN, AHMET; İNCE, ÜMİT; SAĞLICAN, YEŞİM; BALCI, FARUK; and ŞAMLI, HALE
"Association of B7-H4 gene polymorphisms in urothelial bladder cancer,"
Turkish Journal of Medical Sciences: Vol. 47:
2, Article 12.
Available at: https://journals.tubitak.gov.tr/medical/vol47/iss2/12