Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography

Authors

SERVET GÜREŞCİ
ÖZLEM ÖZMEN
METİN UZMAN
GÜLÇİN ŞİMŞEK
EBRU TATCI
ATİLA GÖKÇEK
ABDULLAH ÖZGÜR YENİOVA

DOI

10.3906/sag-1410-24

Abstract

Background/aim: To investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) imaging is correlated with proliferation index in the colorectal region. Materials and methods: SUVmax values of 31 colorectal neoplasms that were incidentally detected during PET-CT examination were compared to dysplasia degree, histopathologic diagnosis, and immunohistochemical expression of the Ki-67 proliferation marker. Results: Statistically significant correlations were found between SUVmax and Ki-67 proliferation index, dysplasia degree, and histopathologic diagnosis. Median SUVmax value was found to be significantly higher in high-risk lesions than low-risk lesions. Conclusion: The Ki-67 proliferation index is an indicator of SUVmax in colorectal tract. SUVmax values can predict malignancy and prognosis in this region. Colonoscopy and biopsy should always be performed whenever a focal high FDG uptake is determined incidentally in a patient.

Keywords

Colorectal neoplasm, positron emission tomography, Ki-67 antigen

First Page

1182

Last Page

1187

Recommended Citation

GÜREŞCİ, SERVET; ÖZMEN, ÖZLEM; UZMAN, METİN; ŞİMŞEK, GÜLÇİN; TATCI, EBRU; GÖKÇEK, ATİLA; and YENİOVA, ABDULLAH ÖZGÜR (2016) "Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography," Turkish Journal of Medical Sciences: Vol. 46: No. 4, Article 36. https://doi.org/10.3906/sag-1410-24
Available at: https://journals.tubitak.gov.tr/medical/vol46/iss4/36